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Your healthcare provider can assess whether dose reduction or switching to a different GLP-1 medication might be appropriate
77 (suppl 9)
32,33 Under physiological conditions, besides the paracrine secretion pathway in the gastrointestinal tract, most endogenous GLP-1 in circulation is locally deactivated by DPP-4 and the liver, 34 making it difficult to directly enter the CNS through the blood-brain barrier
The semaglutide versus tirzepatide comparison shows tirzepatide achieving 20-22.5% body weight reduction at the highest dose versus 14.9% for semaglutide
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