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Study is needed to elucidate the pathophysiology to further understand why most patients have no hypoglycemia after gastric bypass, some have mild to moderate PGBH, and a small percentage have severe PGBH with debilitating neuroglycopenia unresponsive to dietary changes and medications

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MOTS-c, as a small molecular active peptide, has been reported to have potential applications in aging, insulin resistance, cardiovascular disease and inflammation ( Figure 1 )

For people without pre-existing heart conditions, investing in these therapies still proves economically viable according to cardiovascular outcome trialsas shown by their favorable quality-adjusted life year (QALY) figureswhich underscores the broader value of GLP-1 agonists in improving cardiovascular outcomes