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50 Hernndez-GarcaJ.Navas-CarrilloD.Orenes-PieroE

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M.FactorS

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The cyclical dosing protocols used in research (short cycles followed by long breaks) inherently limit total exposure

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In clinical trials, participants lost approximately 15-20% of their initial body weight over 72 weeks, with higher doses generally producing greater weight loss

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The alkaline pH-adapted skin barrier is disrupted severely by SLS-induced irritation

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