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Thats why a compound like phenoxybenzamine can knock down receptor populations after just a brief exposure

This is particularly true in women, as visceral fat mass positively correlates with aldosterone and negatively correlates with insulin sensitivity in women, but not in men (107)

Your body changes through every stage and the idea that a single BMI number determines whether you deserve treatment ignores everything we know about how bodies actually work. Her approach is to be transparent about the uncertainty and let the patient decide: As long as were honest that we have no evidence, if this is still a risk that [a patient wants] to take on, we can do that together. I personally think were heading toward a world where treatment thresholds come down, and Im a strong advocate for clinicians with real expertise pushing those boundaries rather than waiting for guidelines to catch up

doi:10.1371/journal.pone.0222135