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Ferroptosis, an iron-dependent programmed death characterized by the accumulation of lipid peroxide, stands out from the conventional forms of cell death, such as apoptosis, pyroptosis, necrosis, and autophagy

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203 YamamotoK.MorishitaR.HayashiS.MatsushitaH.NakagamiH.MoriguchiA.et al (2001)

Hence, the use of combination therapies to target multiple metabolic pathways to suppress tumor growth may be most effective, especially in identifying cases that induce synthetic lethality, where two drugs induce cell death in combination, but not individually

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