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Moreover, a recent prospective study in dogs with naturally occurring mild, asymptomatic mitral valve disease treated with pimobendan demonstrated increased regurgitant fraction and induction of mitral valve lesions including acute focal hemorrhages, endothelial papillary hyperplasia, and infiltration of chordae tendinea with glycosaminoglycans

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In Europe, the incidence of obesity is five times higher than it was after World War II, and the number of obese people doubles yearly (4)