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Moreover, in DNA methylation alterations of tumor cells induced by GLP-1RAs, studies have demonstrated that during breast cancer progression, tumor suppressor genes such as ESR1, CDH1, and ADAM33 are downregulated due to hypermethylation alterations in their promoter regions

Currently in Phase 3 clinical trials under Eli Lilly, retatrutide is not FDA-approved and cannot be prescribed through standard pharmacies

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