Over time, this style of movement supports better insulin sensitivity, steadier energy, and fewer cravings without burning you out or putting extra strain on your body
Yet as millions lose weight quickly, physicians and nutrition specialists are increasingly focused on the potential health trade-offs
More serious but less common adverse effects require clinical vigilance: Pancreatitis : Patients should be counselled to stop the medication and seek immediate medical attention if they experience severe, persistent abdominal pain radiating to the back [1] [5] Gallbladder disease : Rapid weight loss associated with GLP-1 therapy may increase cholelithiasis risk [1] Hypoglycaemia : Particularly when used alongside insulin or sulphonylureas in diabetes management Diabetic retinopathy : Semaglutide requires caution in patients with pre-existing retinopathy, who should be monitored regularly [1] Renal impairment : Dehydration from gastrointestinal side effects may affect kidney function Specific considerations for individuals with eating disorders include the potential for GLP-1 medications to exacerbate restrictive eating patterns or mask hunger cues in vulnerable individuals
Department of Veterans Affairs database found that GLP-1RA therapy reduced the risk of dementia and AD by 8% and 12%, respectively (Xie et al., 2025)
Plus, it stops the production of glucagon , thus decreasing glucose from the liver
