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S1A, GLP-1RA intervention was associated with a reduction in BMI when compared to metformin (MD = 1.11

Topical NSAIDs (such as ibuprofen gel) offer localised pain relief with minimal systemic absorption and are recommended by NICE as first-line for localised joint pain

In male rats exposed to electric foot shocks, levels of TRP, KYN, 3-HK, and KYNA shift dramatically across plasma and multiple brain regions, normalizing within 24 h suggesting a dynamic and time-sensitive response of KP metabolism to stress [69]

Eligibility follows the same NICE and MHRA criteria as injectable GLP-1s typically adults with a BMI of 30+, or 27+ with a weight-related health condition

By reducing oxidative stress, it protects cells from damage and slows cellular aging