Therefore, both mRNA engineering and lipid nanoparticle design must be carefully optimized before these formulations can be broadly and reliably applied in clinical settings [80]
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The KEAP1-NRF2 pathway: targets for therapy and role in cancer
In fact, NADH is an inhibitor of the TCA enzyme isocitrate dehydrogenase 93 , a protective mechanism to prevent overloading of the ETC and excessive ROS generation
