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Furthermore, the expression of the key glycolytic enzyme PFKFB3 is upregulated and mediates increased PD-L1 expression by activating the nuclear factor B signaling pathway, thereby inhibiting the anti-tumor activity of cytotoxic CD8+ T lymphocytes (82)

also known as cobalamin, is an important water-soluble vitamin

Especially on travel days

Look for isolated vitamin B12 or in a supplement in multivitamins or B complex

Further in vitro and in vivo studies, including experimental models, are needed to clarify the mechanistic roles of these molecular effectors and to validate their contribution to the Long COVID phenotype