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Cons Shipping and storage issues : Multiple patients reported warm medication, missing ice packs, or delayed deliveries

Preliminary data published in June 2023 also suggests that GLP-1 drugs 'could modulate crucial pathways in the pathogenesis of inflammatory bowel disease (IBD), such as chronic inflammation circuits, intestinal tight junctions, and gut microbiome dysbiosis, setting the stage for human trials to investigate the role of these agents in the treatment of IBD among people with or without diabetes and obesity' (Arvanitakis, Theocharis, Popovic

In clinical trials, people lost up to 28.7% of their body weight after 68 weeks

doi: 10.1001/jama.2021.1831 53 YamadaYKatagiriHHamamotoYDeenadayalanSNavarriaANishijimaKet al

Papamargaritis D, Le Roux CW