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Ferroptosis does not require a specific pro-death signaling pathway but is triggered spontaneously when the protection of cellular membrane phospholipids from peroxidation by the metabolites and enzymes, including cysteine and glutathione peroxidase 4 (GPX4), are weakened [228, 229]

These are substances that can cause adverse health effects, such as: nausea vomiting lightheadedness body aches chills low blood pressure difficulty breathing Glutathione is a vital antioxidant that supports various elements of human health

G6PD deficiency is X-linked and thus subject to random X-chromosome inactivation in women giving them mosaic expression of G6PD activities in their individual cells

49,52 This point might be of high importance to athletes

10.1007/BF01958877 16