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You may also call the Center for Drug Regulation and Research at telephone number (02) 809-5596.

The Australian Register of Therapeutic Goods lists 4 SAMe-containing supplements: 3 of these combine SAMe with B-vitamins, another contains 8 additional herbs and nutraceuticals (Table 1)

Cytotoxicity profiling in vitro shows a dose-dependent pattern: cell viability holds within research-relevant concentration ranges but declines meaningfully above approximately 1 mM in culture, a threshold well outside the concentration windows described as biologically productive in the wound healing and gene expression literature

Evidence Ledger: What Does the Research Actually Show

After 3 weeks of running wheel exercise, traumatically injured mice had significantly higher levels of COXI, COXII, COXIII, BDNF, synapsin I, and ATP in the hippocampus than the controls, suggesting that exercise increases oxidative phosphorylation and ATP production in mitochondria, leading to reduced loss of neurons and better recovery of cognitive function after TBI [107]