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Defined as a BMI 30 kg/m, obesity is associated with numerous comorbidities that contribute to significant morbidity and mortality, including type 2 diabetes mellitus (T2DM), cardiovascular disease, metabolic syndrome, dyslipidemia, hypertension, and nonalcoholic fatty liver disease
It is the predominant intracellular non-protein thiol in mammalian tissues, present at concentrations typically ranging from 110 mM in the cytosol, with particularly high concentrations in the liver (up to 10 mM), which is the primary site of GSH synthesis and export
Recent research has increasingly focused on the roles of GLRs under abiotic and biotic stress conditions, revealing how these receptors integrate metabolic and environmental cues into adaptive responses
(2018, September 1)
This pattern reflects the underlying biology rather than treatment failure
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