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In long-term studies, patients taking Semaglutide GLP-1 lost an average of 15-20% of their initial body weight over periods of one to two years

Peripheral neuropathy is a rare but serious side effect where patients experience numbness, tingling, or weakness in their hands or feet

These typically include mild nausea, diarrhea, and decreased appetite, which generally resolve with continued treatment

[7] The two agents operate through entirely distinct physiological pathways: Retatrutide targets incretin and glucagon signalling, with observed improvements in body weight and metabolic parameters in clinical trials