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GHK-Cus gene modulation capacity was documented in a landmark microarray analysis by Pickart et al., identifying 4,000+ gene targets including VEGF upregulation (angiogenesis), SOD2 upregulation (oxidative defense), and downregulation of pro-inflammatory cytokine genes including TNF- and IL-6
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Recent investigations have reported that PIK3CA mutations modulate SIRT4 expression through negative regulation of the epigenetic factor EP300, ultimately influencing GPT1 and altering glutamine metabolism in cancer [99]
