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This is strikingly similar to our previous observations on the robustness of cytosolic glutathione redox homeostasis [21, 56] and raises the exciting possibility that glutathione reductase may facilitate the rapid bi-directional interaction between the glutathione and NADP redox couples, which could suggest that the highly abundant glutathione pool might effectively serve as a reservoir of available electrons to supply the NADP pool under conditions of extreme oxidative challenge

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We validate the specificity of these antibodies to GPX4 by testing them on tissues known to express GPX4 positively and negatively

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