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Keywords: fibroblast growth factor 21, MASH, MASLD, insulin resistance, hepatic fibrosis, efruxifermin, cardiometabolic disease Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver condition worldwide, affecting an estimated 38% of the global population

Telomerase activity measured by telomere repeat amplification protocol (TRAP) The TRAP assay was used to determine telomerase activity

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Chronic illness, oxidative stress, and medications deplete glutathione and may require higher replacement doses

These pigments can accumulate and cause a darkened appearance