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Hypoglycemic drugs such as metformin, SGLT2i, DPP-4i, GLP-1RA, anti-inflammation therapies, anti-senescence therapies, mineralocorticoid receptor antagonists, and stem cell therapies have also shown beneficial effects against tubular injury, potentially slowing the progression of the DKD, and thereby protecting the kidney

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Previous reports in the context of SCI recovery reported a positive effect of HGF in the promotion of grafted NSC differentiation and synapse formation between new neurons and the descending cortico-spinal fibers (Kokuzawa et al., 2003

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