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Medication tolerability directly affects real-world affordability: patients requiring dose reductions, extended titration, or early discontinuation due to intolerance experience reduced cost-effectiveness despite identical monthly spending

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*In clinical trials, weight change was a secondary endpoint .1 Triangles indicate the times at which the maintenance doses of tirzepatide (5 mg, 10 mg, or 15 mg) and semaglutide 1 mg were achieved