Ageing, environmental stress, and poor diet can all reduce the efficiency of this internal assembly line
While weight-loss drugs have proven effective for many, the fact that they dont work for everyone shows how important it is to move towards developing precision obesity medicine
They also included patients with a recent history of obesity, but excluded those with diabetes or who had been prescribed another antidiabetic drug
The main genetic abnormalities - del15q, mUPD, and imprinting center defect - can all be identified using Comparative Genome Hybridization (aCGH) in combination with methylation-specific multiplex ligation-dependent probe amplification analysis (MS-MLPA)
Rosenstock J, Perkovic V, Alexander JH, Cooper ME, Marx N, Pencina MJ, et al