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In mice, CHAC1/BOTCH promotes neuronal differentiation by inhibiting NOTCH1 and both its depletion and overproduction severely disrupt neurogenesis ( CHAC1/BOTCH in zebrafish leads to severe defects in brain, heart and myotome development, resulting in embryonic lethality, highlighting its conserved and essential role (Yadav et al., 2019)

Short-term dosing up to 1200 mcg daily is generally well tolerated under practitioner supervision, to support detoxification and help ease die-off symptoms

Simple routine fit: layers easily under moisturiser and sunscreen without a greasy finish

Jitoe-Masuda A, Fujimoto A, Masuda T (2013) Curcumin: from chemistry to chemistry-based functions

If taking antacid or PPI, take those in morning and melatonin at night