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I checked a couple of examples that I'm not allowed to post about here due to my newbie status that didn't make sense given the data I've seen

Niacinamide (2%) Helps reduce the appearance of uneven tone, refines texture, and supports skin barrier function

They have not been reviewed, evaluated, or approved by the U.S

Semaglutide pens and vials must remain refrigerated at 36-46F (2-8C) until first use, then can be stored at room temperature for up to 30 days

But Im not sure that they really understood the time constraints and also the asymmetry in the information that is available to patients versus health care professionals