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Guidance for industry diabetes mellitus evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes
Patients should contact their GP or call NHS 111 if green stools are accompanied by: Severe or persistent abdominal pain , particularly if localised to the right upper quadrant, which could indicate biliary or hepatic pathology High fever (temperature above 38C), which may suggest infection Blood in the stools (either bright red or dark, tarry stools), indicating possible gastrointestinal bleeding Persistent vomiting that prevents adequate oral intake or medication administration Signs of dehydration , including reduced urine output, dizziness, dry mouth, or excessive thirst Unexplained weight loss beyond expected therapeutic effects Jaundice (yellowing of the skin or eyes), which could indicate liver dysfunction Attend A&E or call 999 immediately for: Severe, persistent abdominal pain, especially if accompanied by fever and vomiting Severe epigastric pain radiating to the back (possible pancreatitis) Black or tarry stools with dizziness or feeling faint Signs of severe dehydration or shock Additionally, if green stools persist for more than a week despite dietary modifications, or if they are accompanied by significant changes in bowel habit (such as sudden onset of severe diarrhoea or complete constipation), medical review is advisable
A post-hoc analysis of STEP 1, 2, 3, and 5 found a small but statistically significant reduction in depressive symptoms with semaglutide compared to placebo
This was the first signal that retatrutide could produce exceptionally rapid weight loss
