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Monitoring Potential Side Effects Despite its overall safety profile, semaglutide GLP-1 does have potential adverse effects, including digestive problems such as constipation, diarrhea, nausea, and abdominal discomfort

Lancet 2(7409):415416

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In the light of the current research, it is speculated that the maladaptive changes in the gut microbiota can influence the central nervous system and evoke depressive symptoms, and the development of depression can influence gut microbiome stability, and both of these hypotheses appear to be supported by the results of human and animal studies [100]