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The higher concentration is just one factor

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In this study, the placebo was normal saline (salt water) applied after the same radiofrequency procedure, allowing researchers to isolate the effect of the active serum ingredients

In contrast, GSTP1 promotes ER stress-induced apoptosis in liver cancer by glutathionylating SERCA, thereby inhibiting pro-survival MAPK8 signaling 50

Annu Rev Pharmacol Toxicol 2013, 53:401426