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Despite the longer follow-up in STEP 5 (104 weeks versus 68 weeks in the other STEP trials), STEP 5 was again not designed or powered to assess the impact of semaglutide on the development of weight-related comorbidities such as cardiovascular disease
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However, viral-mediated liver-specific RAMP2 overexpression in mice does not meaningfully impact any metabolic endpoints in both chow and HFD-fed mice [116]
However, sustained weight loss has historically improved mood and self-esteem in many patients
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