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The same finding has not yet been confirmed in clinical trials, although there is evidence of striatal vascular formation within cerebral capillaries during the progression of PD (Yang et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 157.Alexandrides T, Moses AC, Smith RJ

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Methanolic leaf extracts of Hawaiian kava cultivars showed stronger binding inhibition to several CNS receptorsincluding GABA A , dopamine D2, opioid (, ), and histamine (H1, H2)than root extracts, suggesting that compounds beyond the main kavalactones may contribute to the pharmacological effects of kava leaves

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