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While estimands do not solve all problems of trial design and interpretation, this new concept will enable trials to be designed more appropriately to obtain relevant information to address the clinical question(s) of interest

Just be consistent and use the same method over time for comparability

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Weight Loss: The average percent weight loss from patients starting weight after these 17 months at the maintenance dose was: -15% weight loss from baseline body weight at 68 weeks at the 2.4mg dose -In a two year follow up study, those who continued to take semaglutide at the 2.4mg dose were able to maintain an average of 15.2% of their initial weight