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Moreover, recent studies have identified novel molecular targets such as ULK1 and PRMT5 that modulate immune resistance mechanisms and can be pharmacologically inhibited to synergize with ICIs, further supporting the rationale for combination strategies (133, 134)

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Risk Considerations: Understand and weigh the risks associated with both surgical procedures and long-term medication use

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Keywords : GLP-1RAs, CVD, diabetes, CVOT, glycemic control, MACE Over 90% of diabetes is classified into two main types being Type 1 diabetes mellitus (T1DM) and T2DM