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No published RCTs in humans with insulin resistance or metabolic syndrome endpoints exist as of this writing

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Clinical trials show that semaglutide's appetite-suppressing and blood-sugar-regulating effects persist for up to 10 to 14 days after your last injection, though at reduced strength by day 8 or 9

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The mechanism by which GLP-1 receptor agonists work primarily involves enhancing glucose-dependent insulin secretion, suppressing glucagon release, and slowing gastric emptying