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ELISA assays showed that BV2-metformin-loaded PLGA lowered pro-inflammatory markers (TNF-, IL-6) and boosted anti-inflammatory markers (IL-4, IL-10) in both the brain tissue and blood samples 19

In this, pentadecapeptide BPC 157 consistently (grossly, microscopically, and biomechanically) cured burn injuries, and counteracted corticosteroid (6-methylprednisolone 1.0 or 10 mg/kg/day ip for 21 days)-induced impairment of burn healing (Sikiric et al., 2003)

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Different pathways have been recently identified to play a key role in the escape of the immune system in senescence, highlighting the potential development of significant senolytic therapies in the future (Fig