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Safety signals of special interest, including pancreatitis, gallbladder events, neoplasms, and suicidal ideation, were adjudicated by blinded expert committees

Peroxidase Conjugated Goat Anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37C

10.3382/ps.0711781 214

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The ability to obtain strength data from the entire cohort in the VALIANT trial should help to answer outstanding questions about potential biologic effects of VPA in subjects with SMA, and whether this agent merits further study as a therapeutic agent in this disorder