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Since glutamate is one of the brains major excitatory neurotransmitters, this pathway has drawn interest in conditions such as obsessive-compulsive disorder (OCD), depression, bipolar disorder, and substance use disorders.11 29 The evidence is still uneven

Lysis was carried out with the addition of lauryl maltoside at 1.5%

658 Likewise, expression of glutamate transporters is reduced in astrocytes from human tissue and animal models of HD 112,659

However, investigation of these factors in preclinical studies is limited due to the time and expense of generating transgenic mice and the variability of the currently available rodent models 20

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