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The GHK-Cu peptide should be considered a promising neuroprotective agent capable of preventing the development of common age-associated neurodegenerative disorders

The protein structures corresponding to complex (PDB ID: 2FLU), KEAP-1 monomer (PDB ID: chain A of 2FLU) and HES-1 (PDB ID: 2MH3) were retrieved from the RCSB Protein Data Bank (PDB)

Studies reveal that DHFR inhibition induces ferroptosis in GCH1-knockout cells, while BH4 supplementation directly reverses this process [65, 68]

The 2% solution came first