Injection-site issues: redness, swelling, or irritation are common to any SubQ injection and are made worse by poor technique or low-quality product
These findings suggest that despite bearing a reactive electrophile, C1-27 did not bind to cellular proteins indiscriminately but appeared to exhibit certain degree of selectivity in target binding
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Instead of targeting TAAs, UniCARs are engineered to recognize the human peptide sequence E5B9, also known as the UniCAR epitope, which is a fragment of the human nuclear autoantigen La/SS-B and absent in living cells (Jureczek et al., 2019)
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