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Each dose step can be extended by 4 weeks if needed, or maintenance at 1.7 mg considered if 2.4 mg is not tolerated
The link to cerebral folate deficiency was a significant finding in ASD patients because ASD symptoms were effectively reversed by folinic acid treatment/supplementation [73-75]
If you must switch, allow a 48-hour washout period after the last IM dose before beginning SubQ administration, and document the transition as a protocol deviation
When patients report brain fog while taking any medication, including metformin, it is essential to consider the full clinical context
It can also have potential drug interactions, for example, berberine can inhibit the metabolism of blood thinners like Warfarin and increase risk for bleeding in patients who are taking these drugs
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