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These changes enable once-weekly subcutaneous dosing and maintain steady receptor activation over time

48 As an add-on to insulin with or without metformin (PIONEER 8), oral semaglutide (at doses of 3, 7 and 14 mg) was shown to be associated with superior HbA1c and body weight reductions versus placebo as early as at week 26 and achieved further reduction in insulin need (except dose 3 mg) at week 52, without significantly increasing the rate of hypoglycemia

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