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Mutations in the other genes of the PDHc, that result in PDH deficiency syndromes, are inherited in autosomal recessive patterns

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it is a clinical requirement to ensure you are receiving the exact dose intended by your provider

Studies in obese rodents fed high-fat diets for extended periods show that diminished carnitine reserves in skeletal muscle are accompanied by marked perturbations in mitochondrial fuel metabolism, including reduced complete fatty acid oxidation, elevated incomplete -oxidation, and impaired substrate switching from fatty acid to pyruvate oxidation