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Comparative Mechanisms with Other Agents Compared with metformin, which improves insulin sensitivity primarily through hepatic and muscular pathways, GLP-1 RAs act centrally and peripherally to influence appetite, glucose metabolism, and systemic inflammation

Food and Drug Administration, and no claims are made regarding the diagnosis, treatment, cure, or prevention of any disease

The recommended starting dose is 3.75/23 mg for two weeks, and your provider will increase from there

GLP-1 meds accelerate this by causing weight loss faster than the skin can keep up, which can cause additional collagen loss

70-80% of women with PCOS (PMOS) face insulin resistance