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However, GSH is found in intracellular organelles including endoplasmic reticulum (ER), nucleus, and mitochondria to control compartment-specific needs and functions (Mari et al., 2009, 2010)

PEG modification increased the stability of protein and peptide drugs, increased the solubility, reduced the immunogenicity, prolonged the residence time in blood, reduced the protease degradation, and reduced the frequency of drug use

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