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In addition, phosphorylation of two further serine residues (Ser100 and Ser511) by PKA mediates the recruitment of 14-3-3 adaptor proteins that hold CaMKK2 in an inactivated state by preventing dephosphorylation of phospho-Ser495

Resulting plasma was transferred into a polypropylene tube and 150 ul aliquots in micro cryotubes were flash frozen in liquid nitrogen, and stored at 80 C until analysis

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Moreover, the mitochondrial abnormalities and elevated ROS levels have also been implicated in the pathogenesis of IIM (157159)

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