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It is converted to coenzyme B12 in the body and in this form facilitates the conversion of homocysteine to methionine (methylcobalamin) and plays an important role in converting methylmalonyl-coenzyme A to succinyl-Co-A (fatty acid and amino acid metabolism)

Lip-1 is rapidly metabolized and exhibits a short elimination half-life, which may compromise its therapeutic efficacy and reduce patient compliance due to the need for frequent dosing ( While high-dose -tocopherol supplementation may exert therapeutic effects in specific contexts, the current evidence on the safety profile of high-dose -tocopherol supplementation is still inconclusive

Antioxidants 13(4):455 Kanda H, Yamawaki K (2020) Bardoxolone methyl: drug development for diabetic kidney disease

doi: 10.1016/j.cbi.2023.110835 52 PangCZhangHLiuYTangNTianKMuYet al

Be patientreal transformation takes 8-12 weeks