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While this limits systemic exposure, it may increase local receptor activation during the immediate post-administration period

The compound shows effectiveness across a wide dose range in animal studies (10 ng/kg to 10 mcg/kg producing comparable results), suggesting that more is not necessarily better

HGF/c-met signaling pathway in metastatic process The c-Met, and its ligand HGF have been associated with tumor formation and progression to metastasis, with MET gene often overexpressed or mutated

Under these conditions, we still observed a significant reduction in apoptosis compared to CGNs treated with AlCl 3 alone (Figure 5(b))