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Targeting the PANoptosis pathways in NAFLD/NASH PANoptosis, a newly identified form of RCD, has garnered significant attention recently

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However, we found that the exendin-4 antibody light chain fusion (Ab#2_EX4) had a GLP-1R activity half-life of 11 h, with no improvement seen in stability over the Ab#2_GLP1 fusion molecule (Fig

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The same finding had been reported by a prior larger meta-analysis (6,914 patients with overweight or obesity and T2DM) over 8 studies 184,185,189,190,191,192,193,194 , but only when the largest study that also included non-diabetic participants 193 was excluded in a sensitivity analysis 195