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Glutamine metabolism not only supports the tricarboxylic acid (TCA) cycle but also reduces glutathione (GSH) synthesis and increases lipid hydroperoxides [28, 29]

Growth hormone levels naturally decline with age, and this decline is closely associated with many of the physical and cognitive changes that come with aging

This heightened glutamine metabolism and the hexosamine biosynthesis pathway distinctly regulate the production of IL-4 and IFN- [137]

References Witschi, A., Reddy, S., Stofer, B

In this article, we summarize the latest research progress on diagnostic markers for DPN in terms of its pathophysiology as well as the mechanisms by which it may occur, expanding new ideas for the prevention and treatment of DPN