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Moreover, RF ablation has been used synergistically with deformable liposomes (transfersomes and ethosomes), further amplifying delivery efficiency by facilitating both mechanical passage through RF-induced microchannels and biochemical fusion with skin lipids [262]

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Central behavioral effects were subsequently shown to be abolished by a non-selective MC3R/MC4R antagonist, confirming receptor-mediated central MCR activation (PMC PMC1572913)

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