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Activation of MC1R promotes cAMP accumulation in melanocytes, upregulating tyrosinase activity and accelerating melanin synthesis

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After ferroptosis was inhibited by ferrostatin-1 treatment in C57BLKs/J mice, urinary albumin to creatinine ratio was decreased, kidney tubular injury and kidney fibrosis were improved, HIF-1 and HO-1 expression were suppressed [78]