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Under hypoxic conditions, L-2-hydroxyglutarate (L-2-HG) was proven to be generated by lactate dehydrogenase A (LDHA) and malate dehydrogenase (MDH) 88,89

Due to the presence of theNH 2 groups in their structure, they are cationic, which makes them able to engage electrostatically with negatively charged macromolecules to facilitate gene treatment and drug administration (Shokati Eshkiki et al., 2024

ACS Nano 9 (8), 78747885 (2015) X